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KMID : 0387820070140020167
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Clinical Pediatric Hematology-Oncology
2007 Volume.14 No. 2 p.167 ~ p.175
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Outcome of Multicenter Study for Korean Children with Medulloblastoma
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Park Hyun-Jin
Baek Hee-Jo
Seo Jong-Jin
Suh Chang-Ok
Sung Ki-Woong
Shin Hyoung-Jin
Ahn Seung-Do
Ahn Hyo-Seop
Wang Kyu-Chang
Yoo Keon-Hee
Ryu Kyung-Ha
Yoo Eun-Sun
Lyu Chuhl-Joo
Lee Kun-Soo
Lee Soon-Yong
Lee Young-Ho
Lee Jun-Ah
Lim Do-Hoon
Im Ho-Jun
Chung Nak-Gyun
Jeong Dae-Chul
Jung Hye-Lim
Cho Byung-Kyu
Cho Bin
Choi Eun-Jin
Choi Joong-Uhn
Hwang Tae-Ju
Nam Byung-Ho
Lim Hyun-Sun
Shin Hee-Young
Hah Jeong-Ok
Kang Hyuoung-Jin
Koo Hong-Hoe
Kook Hoon
Kim Dong-Seok
Kim Seung-Ki
Kim Il-Han
Kim Ji-Yoon
Ghim Thad T.
Kim Hack-Ki
Kim Heung-Sik
Ra Young-Shin
Moon Hyung-Nam
Park Kyung-Duk
Park Byung-Kiu
Park Sang-Kyu
Park Jun-Eun
Park Ji-Kyoung
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Abstract
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Purpose: Medulloblastoma is the most common primary malignant brain tumor of childhood. In spite of improved multimodality approach, 30∼40% of children with medulloblastoma still suffer from recurrence. Furthermore, many survivors have significant long-term sequelae. This study was undertaken to investigate the current status of childhood medulloblastoma in Korea.
Methods: Questionnaires were sent to the member hospitals of the Korean Society of Pediatric Neuro-Oncology. One hundred and sixty seven cases from 20 university hospitals were collected and analyzed.
Results: The median age at diagnosis was 6.9 years and the male to female ratio was 1.9：1. Patients in average risk group were 77 (46%) and those in high risk group were 90 (54%). In average risk group, 1 patient was treated with operation only, 4 were treated with operation and radiotherapy, 70 were treated with operation, radiotherapy and chemotherapy, 2 were treated with various treatments. In high risk group, 4 patients were treated with operation and radiotherapy, 9 were treated with operation and chemotherapy, 58 were treated with operation, radiotherapy and chemotherapy, 16 were treated with high dose chemotherapy and autologous stem cell rescue, and 3 were treated with various treatments. Median follow up was at 30.8 months, and 3 year EFS was 65% for all patients. The 3 year EFS were 78% for patients in average risk group and 54% for patients in high risk group.
Conclusion: Diverse treatment protocols have been applied for childhood medulloblastoma in Korea. This study inspired the necessity of nation-wide protocols and prospective multicenter studies for medulloblastoma in Korea.
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KEYWORD
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Medulloblastoma, Children, Treatment, Korea
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